	   SnapGene      GACGGATCGGGAGATCTCCCGATCCCCTATGGTGCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACCCACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAAGCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCACTAGTCCAGTGTGGTGGAATTCgccaccatggcgtgcaggcagagaggaggctcttggagtccctcaggctggttcaatgcaggctggagcacctacaggtcgatttctctcttcttcgcccttgtgacttcagggaactccatagatgtttctcagttggtaaatcctgcctttccaggcactgtcacttgcgatgaaagggaaataacagtggagttcccaagcagtcctggcaccaagaaatggcatgcatctgtggtggatcctcttggtctcgacatgccgaactgcacttacatcctggacccagaaaagctcaccctgagggctacctatgataactgtaccaggagagtgcatggtggacaccagatgaccatcagagtcatgaacaacagtgctgccttaagacacggagctgtcatgtatcagttcttctgtccagctatgcaagtagaagagacccaggggctttcagcatctacaatctgccagaaggatttcatgtctttttccttgccacgggtcttctctggcttggctgacgacagtaaggggaccaaagttcagatgggatggagcattgaggttggtgatggtgcaagagccaaaactctgaccctgccagaggccatgaaggaaggcttcagcctcttgattgacaaccacaggatgaccttccatgtgccattcaatgccactggagtgactcactatgtgcaaggtaacagtcatctctacatggtgtctctgaagcttacatttatatctcctggacagaaggtgatcttctcttcacaagctatttgtgcaccagatcctgtgacctgcaatgccacacacatgactctcaccataccagagtttcctgggaagcttaagtctgtgagctttgaaaaccagaacattgatgtgagccagctgcatgacaatggaattgatctagaagcaacaaatggcatgaaattgcatttcagcaaaactctgctcaaaacgaaattatctgaaaaatgcctactccatcagttctacttagcttcactcaagctgacctttctccttcggccagagacagtatccatggtgatctatcctgagtgtctctgtgagtcacccgtttctatagttacaggggagctgtgcacccaggatgggtttatggacgtcgaggtctacagctaccaaacacaaccagctcttgacctgggtactctgagggtgggaaactcatcctgccagcctgtctttgaggctcagtctcaggggctggtacggttccacatacccctgaatggatgtggaacgagatataagttcgaagatgataaagtcgtctatgaaaacgaaatacatgctctctggacggattttcctccaagcaaaatatctagagacagtgagttcagaatgacagtgaagtgttcttatagcaggaatgacatgctactaaacatcaacgttgaaagccttactcctccagtggcctcagtgaagttgggtccatttaccttgatcctgcaaagctacccagataattcctaccaacaaccttatggggaaaacgagtaccctctagtgagattcctccgccaaccaatttacatggaagtgagagtcctaaacagggatgaccccaacatcaagctggtcttagatgactgctgggcgacgtccaccatggatccagactctttcccccagtggaacgttgtcgtggatggctgtgcatatgacctggacaactaccagaccaccttccatccagtcggctcctctgtgacccatcctgatcactatcagaggtttgacatgaaggcttttgcctttgtatcagaagcccacgtgctctctagcctggtctacttccactgcagtgccttaatctgtaatcgactctcccctgactccccactgtgttctgtgacctgccctgtgtcctctaggcacaggcgagccacaggggccactgaagcagagaaaatgacagtcagcctcccaggacccattctcctgttgtcagatgactcctcattcagaggtgtcggctcatctgatctaaaagcaagtgggagcagtggggagaagagtaggagtgaaacaggggaggaggttggctcacgaggtgctatggacaccaaagggcacaagactgctggagatgttggttccaaagctgtggctgctgtggctgcctttgcaggtgtggtggcaactctaggcttcatctactacctgtacgagaaaaggactgtgtcaaatcacCTCGAGGACTACAAAGACCATGACGGTGATTATAAAGATCATGACATCGACTACAAGGATGACGATGACAAGTAGTGAGGGCCCGTTTAAACCCGCTGATCAGCCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTC  B;   "   '            &   &      (            #      9      "            *   &         !         &            %   +                                   (                           (   !   $      3      )   2      *       $   !          +               %      #         (   +                 )   &   <   %      &                        +   -                                    &   *                                        &      #         #   -   &   -   !      "   8   )                (   "   /                                    $                   $                           +   +         *   -               )   !   "       ,       &   (      )   *                                 	               "   +   ,   &   (   )   "   &         +         *               -   (   ,   ,                "      (   %      -   .   ,            *   6   !   (   #   /      %         ,      (        " š{Ò–º	OÄÜyz{€…”•¶äíî’“¼d'dæqó¤àò'  š1›½Ùo,oÓäl»	 
»ÅÝ–Ÿ·cCH\ÉçDrôñÉ™8£p · °³(]h€	|�ï Ò¿jºe¥J¸ó Ø �í|—'
PÌ†Áå”å…½Xe(µ‡9�ùáx 	 d -´¾pÕßý|Féf¼ÆÑÞá—Üènôsš& ¶-p&Mm»@	¼	ì	N
(O Ö6®ÅDú�¼îEÿ$ªò'µõ9ÒYq�&  ‡œ ¬™åF$µü
7
[
¶š¸d-3Njö`£Õèõ×°„Êå¤ñË ›2ÚÖÔ®0øp
vùmƒ‹$õIÃÏ]ÊŒ(  ±e³©÷ý�¶âi�ñ?D–,i}‚¾ÓÀká�»{!Êà~ZK E¿”F{^œðÅÚj„©¿3T‘ ¸ mŽîó)¡±
ä!¡Ùù|ZÅf±d{âZ¦Û¹ô g 	¶´9�	
è
M°°'¦Ñ-
è# ½ ‚Å(
DÓ¾Y¨K[sÀ÷ú¥xˆ¾×=~�úÇ¶‚˜ây � Ï@sÊÍY�œe>G‡®¶Ý%†ûfœBLv ]9 • U6Q}Øêùî}¾Ã*Š˜_
�
¾
£è)2QÂÊæy•Ñ”ßñs{–¯Nš«¾)D¶Û¶Ñ¸K:îžÓ– Ù LÏq	QÍæt±·ëb—²f1ãªú" e ÓÖëñ7fˆ¯
›ßâï�ÊM˜Ñ¯µÚÝé1qù^vy½J› 
 ?qÑsÔÀ	Ñ	ò	^Çf'o‰�t×Ãs n .µ¿à}&gïû	Ã	ô	ÌÒdNõyÓ.#A¹]‰ y -šþGê:G½‡ÇæêñXŸéÁ\¹þNÇ* © p–#'˜³YÍ/	z	í	»
Ñ
XÉ)¡á)Ò>E\ûîï«óÛø�ö:ûZ«& Ykq—Ý&j‹•nâè]	½	`ÖhP×Æ‹Ù‘k­ÅF �(|ºÓå‚â ¬ ·N±%	A	¡¯é„ý½aíurŠ× A.Ä-.¼O
Û7Eí7%Fû¶»! 8 Ñ h8háæúG5%¶Ð

\
‹·½¹Ö.KŸž÷vÖI Þ ˆøÂÓ¢	òåö–Ø‹”»¥Ì ð �š8ýÓ	™›§ÍZenŒAO¤*’˜±qËÙÚ&    ¡­¹ØSå�	8
¤
¬¢ß!4k¹
aÙé=…�˜æò[°Âðò'   r~§ú´þÇ1ù+
“ºöö2XK|ËYl« ž ê ¼AÊ<¯GÖ	)	E	q
¶
fú¨ÀŒ¤)�Ðˆ‰2| ÷ œ3“Ûd%kõ 
>
Žn„®é%˜�J¬^¢�Ž{V% š Yd)s×uÕJàÁX
k
|
š
*w�"0¾ÔØÎlÄpt“ÇXÅ…+ ²…±´z§ªj¹o	L
Y
¹Â'0BE~ƒ¿ã"¬Ãl
Ž°¾b|øÞá³|  f#øi·Þ8ãù	-	x	Ï	ð	˜
(Ô—È.ÔØjãÃ
HT[L ] _ Ü¯�ñ2	!4ž@rj³µÁ	¨¼Áù">†z   s È
5þTuÐc
Ú
ù
òí-­â,_P¶@Ë±ÏÆ p mÎÅfàÕ$Ä4UˆG FŽÀëGÎ|¨ûÛ*k…ª%CþE L �·ÞNQÚË
ñä,�y‰‚ÆÀ ’|Û * Ô Óì#Dw•ÿ_�Å	bð_ a ç CôZ	}	S
„å÷5Ø²_)70t2dgÌô‹þ‡ C ¹ ü 7"}» ËãÄ6R»Üº À n�ÁÅ„;*²
Òú8Âeº|@ [c	Y�D( 0…ïWÜ©¢É 	4	#r¢Ú,}[ªÆ<Pg÷´Â+OÕiJ§Ù	õ h è
4ÙV
Œ
 g�AM±(ƒŠ uªýT·_(L‚ýj‡tlƒ·ýE³Ï8s±uÒ�÷9k› ¦ ·¢µ’ó:‚�Ü
é
`N…t§.`'À ªâŠ_‚	ö	.
6;ÊRÝiß{é kŒ	¼ÔA¦©ÁøZäoy¼ÃØÈXÙ€É w Ï f)
EŸZ×è\tûz¿»YÁ·ƒãz ¾ å 5ƒ‚Æ,Ö¦'€5>žö™B u Å û'AI·¿ÿ$.LN2â,m‰ª¸û_w ]®ú( ÐAt*ÊÎö‡=	ö
[¿<ˆ«)ÚÞ"&¬W¹òü&g/ü� ¶kny	!¸! { ‘ i wå\x
	•	µH�è0Iø¡,Cg¶ã_ÑP^h$ > ¥ �¡…ìCfpe
V[¯
íñ59=¯á!P42IWòY^w)/® ! Ë Z�ÉÒ?·S‡ìBM$ü3 k Ç Vzëú7IÄ@¾™
$
`
$*-3Ü³á‰•—°)O›¬·ëÒñ·V§¹:6;\Q³û † Z7~ïdÉAJ	š	ô4Ét|R¿ÈÜ›Íï=p) Y – ² Ê JR�~¿+›!³¿
RËXz¯àò	fµ}›ó
·¡9“Ðý?Ÿ—L2 3 R /œÙâ‚R‹ñ�
Ü
¤éÃçOˆ–Òÿš.€*E$Ò.‹›¬ÌLo®º/7®ÌÔ†¡àŽÈ ; Ávk²¸c¢¥a†þ4�˜³!¡Îë2Íòû5e* H Ú “ç½’®V`ê<ÐzÜ	IRúþ/=mç0@ˆRg –£îNj>°  QP:1œ~a	r	Å
ä
û
n6äïu»Áìy9C¤ 	ãaäw$ #M]kÇðöÔ
/ÎýCKíWclx‚�ÁäÆTþ5QT«”! ¶ ™n+nìzÑg•ÿ	NÛË“ìŸÑb¾»G&òÈœøow·ñ  Ô˜%E#?	uÐàl‚µNŠ™Û,2ôi_Îþ#‹¯ƒäðX f òzµ8°
œãð>+hY°z&¾+ � ” ¼ Ì×éøX)‰½
=CP­ÒÐÜ$°¶ÞêðrúCJwÖ0JœÆKuµ\ ,>ÐÒ%rÓ	ó	®
]šË®&pðžux¸Ò-@ « @–Üo•²-X$	Ð
_ÈgÚà(ÑŠì÷ú{Œútºá  Ý 7à×ÁÏ¡	Ò	
Š¡J‘•p�ØñŠÙH r@tÕ	=
{

Œ£õ(ŽÓˆÄ% r Û®y	4hð	,	1	n	w	Î	ï	K
ø
¸ÁÓÇ¬â!×^øÝ²G°yÅ ) K o �¶Òë"CvlÍÙÄ	ÍÄeã+ÔŽÿ$BFý^# B û /ÀB~VÛ¨È	|	öº|Oö^Ô/5sIQXºŠ S¥©á‰'�ü�Øõ	‹
iÉüDQ@tz&j ‹�+@H¶þ@ÖçÕ1YyáÂõºWXÿØAÈ( z )ÿ†„ë[w		<	Z´¾�ªÙì !4Hë +1Hñ]Ÿµjmâ#·.O­+ … .y�›áHcšÈ ?²½@Q™	
#à‡ˆÈþ(òš ¶UË­56< ß G "0;}`	Ó
ã
Hmãýý3êÿS¢íñ  Ž “ m—Ð$(y´¼
k´*’aFI¯Õ/‚Çã÷´ï[nv ª •?qÎÊ	‹ ¢Ù%IÒï”‡ù,‹ŽG  Úê¤kÚÇ×0	{	î	·ÃÈâ*Ó]�÷sÜEü iÄ) F „ (xŽ…à™ÇZ¼	_	˜	
Ò
Y³"†ë3ý?Õüx*Gðþ¬ô4i;×¬& lßÙÖ^	—	² !jŠŸØÇê2üŒ®)FöýÔ.“+�âÖÃm
< } ÐãÞ	'z†–—ã	¾	a±iHÄÅÆ€�‚”•úû’,-ef)*}~€»àá ÓÔÕÂÔæRS`jklãä	% ~ H	ÑäZIr˜akŒ˜é	bwIQ�ƒ–“l%9BÆgûaƒåí Âˆ
({‡GoäP	¿	û	×ÖÇ1ÚmG‚EI¼'èÕçTé& I{­ 
~ºåó™]çJb™²&	B	cJ„°ê£”þmv^<¸b„Ø x–_sê	E§…&.CÝåUvž¨s‹¢æî  ¡ [¸Ol�¥	ã	R—¢¦ø@œ:ÇØ#ü.- . ­ ÒJ� xŽ’¾ªbîhC a�Öˆ½åW	À	P
œjù·a­Ö ‹ ív.1~/^HQ	¯	ü	
Ø8;‘F‹Ûâ¬üFUê >Ãð:‰/Åû|pt
JÈ2]rî8nmè½(Ž¼è# B?)M²	ß	×ÜBKƒH&ƒGJée+  +J®/c»Ãšâçû�Kcà&.³¸	ê	5
]
÷È×’L˜øq‹•ÿ®”- § |'iö+!HóEhÑà'	C	

i
¹
dŒ‘¦¸¾K…/?ën«×_Õ!¹ÀÅ Ò ƒæ9O Rs6·±wƒÂÊ…Ù 9 åiôŸ¿g^èšïH	±ºæï.7ª Ÿ¤Rwï=<J~c @  ‹—‰l5
:	¨óOÓ/´HqVwµï <y&tùÅÔ£	�F_'Dô÷‘Œæ+¦tç ß ')ã$¥Ã	g
†æ£Ñ á `ÿ©ë±‹åÞ—Ù•¼Ÿ©Œ’Í ¢ í ô o¤÷±ûî92PmS]œyBPUèÈ$„/mÏ¨½ ñ ÿ P]\ŽšÎ£ùA [²rÚý+¥ € ¹ž›¡Ìrþ†	ä	¨[fo�˜�¦“;KÌdÛ°ÓÝ  ¹Y¦	Ô	|–otR§†ÌwÊ¥+™YÙœ.n  WV«X�ê5“Þã©6@¿ciq“yñ& 	×à{Ó"S¥T	
¥
«
Í
y£à"•#ˆË‹4s€«Èï`ÝDß±Ì´*  / N ® H£‡Ž…§ºT‘æ	¨­WHó;lvbê{	†™çS\¦ó(1  ¢K®ÑÙÜêu�	9
‡
Ÿ
óg‘ºÚÎæf>‘óm"ÃA  Ö C½˜×D±Ÿú”´÷Yàì¢—¡ bbÈ‰¾æÁ	íd»÷LŽçZDŒ¸’® s¨ûLµ2X	,
Q
Ø
pÞ	3îÂb× ã ‘îÿù%�U³}Ìkúmu¬Ê„ w2ËC°×>	*	ý	ALgÙ�*Œê‰­Ðý3sV  , ‰ Œ Ÿ î/‹=ÅH_K°	r
ˆ²Á¥9’G‰�#7@ÖàcGë ë :Õ%Fy½Ï‹Ÿñ0§íF	R	è	
·
©ÜÑã¾³Ïþ BíïIû7<ÞŠò} ÄGN\Æüc!
ó
Uoê83‚ï;K9­T2Ÿ™¦&6W$ ø ;i¦pM	u
¨
[…¯™Žnéô� ?�Ë4<ÜŠ&bË®í
9É�)½8& # ”ñe0lö} ¸aqf	?
�K2&>^sò_o£Ð¾|aéŽ” › Z—1ÕÅqž�'ÔYN¾Ð†«ø# `ÍÀ’Ö@Ôü*DN¬	à	2
x
}
ýŽÝLÏÒu™K9£êf> *òKáÂYŠ	³	l
€
+^|¹Ù{Â„”IÛ!íO e¬CtØæv «�	Ç	
›
xØ#¿Cmß„ÈH€Æ# ¯0€¼ã'\k	¹	&
ºÃx„žµÀãäi„W¹ c´†8I- c ,³†µÞü{«Õèe­L/´º÷ë	6
M
Z
o
ø'#5­ÄçMmù�¢Ôó©´Ñ&  d“²íE¨µöüŽá›
ç
C Ø{Œc¯¨ß2SÐ,	}�Y- KTÎ?rÉ5P|ÄŽ›½Âdp	^
ç(1FÉ“M™r–±¿Úö¤<}ù›â©•! m êð9îúe‡	Ð	ñ	ÉLcÐ†ÆÙ0WxÖ"I\r MÆ ¨ j,"—%i”°á.	\	y	º
WÕDèì=í¬Ä`Ú‰ªÖ" 7 ï g÷ù7¸4RäÒŽ	£
«˜ÞÌÕñY‹ @ž�¸äØ<—ºÁ&8 ™ é ö Xq}¦ù(’³ý$Æ;IjßôFÀW(	D	

j
™
µ
)e�’§¹¿!/—€kJo¡Xª1zU) \ ^ °"¦StÏÝ7ø¸b
—
 '3&/Aqì«²´Â
+¯½aÀÂ	=?ÎS Ó ÝþPÊ
axˆú#Ã‡{Ú ` „Ä:3	"ƒ+©;¹ÊÁb1fËý†  ç^K^¡‘ò�U
5†Ÿs:_k¶²ÎÜ7rh„LÞ_€ö8¿ t Ä je»#¥&+©»·^\(   ¤ Éõ ÈhÿvÑäBo”	d
õ
;Uçð/8«÷Rñ ®VXAfµÐ(" 2 Q X ± É I6�ðI	#
Û
ó,²®™-Q|êð9Ì>²oK�Ç/ : ÆæOÀ9‘­U_é›yÄ
ú
.5îù.<jÀ¡ã`…ÅSx€‡4QÌv4i=“d µ » ˜m<ÏOgëžÐ½ïI%Åð =6nW	
ô�öð‰?à A q ú ŒR¨Í	Æõ«á ûCPÖ]rHWx !Š€±;	â
©GÔ0™µ´5VÞ¶ E ƒ '�>ÏÆ`†ÆDÿFu GÁ‡HÕO	ú	°žÕGŒ(Eõü+’úÿ&çÁè z^¤	ÿ
D¥›©"]ÜB-T,§ =�ì9uú}�›\qøl«ç�  *‚ä.õfr-ß·	h
öÇå-©~ªÁ “} à (#%k¤	Ä9	œ^Š� ó þ ¸öO\ËsQx¥ËvTçƒc*¤§¼ÒÜ$ M ßUR¦�Ûé	ª
Ì
òG�‡Ê?zÍÇåep’ÜRÞ³ Õ â B¼íKažc$³²æßët¡‘–  + ˆ 9Ô$ExÎŠŠž=ìç	‡±6"Ïñr½Î ;MŸ­`L	e	ì
Zñ5`7�“ _–ñ  Cª‰	œ	«	Æ	w
]ÁÞŒ˜ÓÚ 8¢½ª÷  b Í>qÈ’ÝD´Áõ~	æ�zæhVÙõ³£…1Ï+�Ð$ ˜ è î õ p¥ø‘²üï6:$3QV†[	�	´
 ËXC·IwÙ;–ÿˆ©Õ [ Ã!ÎT
É
…^*Í6
`gÉa0eÍõ¾ £ Ã d¬nÃ
:ø
T;iöQ"~é%*~8eu3[hnŒ’ ´ º Q°
�ªÏ¼úB³Ýß D ‚  ]†Œ=þ
Ô~�š¤!\ÅùþA,SÀ ò ý -T£�,8	¶	›]¤¨~Ìäd‘ÛÝ¦²» 8A»^LÍ�d	ˆ	æ	#²!Òs7¡¼4ö6 Â p�ÂÇÍ#…³
Â
È
9	WhåõÌf}`d•ÎZŽÔ � º…¢+‡	å	Óœ©±\Ž™£§øÜ¿5±Þ+ Á oÆ¥¦ÿÁ
ûüVgžŸ ¡¢âãäôÊË�ÃLMNOAB\]^_œÍ÷
N4œ�+ Ÿ6ŸÞ<S€œ§sÅ 	C
?TZg|ýp9ž”Ä<P»;C¡æÿ�eO:Ež Ì ºÌÊUsþq:xË=,h•¹ûµî,$fKåÝ
 ð(��Ý-ZÂtµ!	—TÛ¦=QPêj™�+;Ÿ* =X[¸½ªÆ5	$}òpuÍ[hS¨‡\ÇŸ<FQT§øZç Öž/PoÚF- 1† 7 ßT€¨N	£	§	Õ	D
ƒ
ï
@^c}£-~Í«šÅ¼Ú<�•D¢Ã¨˜ö  žÍ�
¡�Kry”ôºBd®¶ï%æÞ Wº5Ë	¬ç¼0Ìäªi–‘j éÚW
6ehÀN²´)rg„zˆ‹ò i Í X»YVktëÿ;ß,>-7Aü™¥-”L) ' ç)@#T‚Þ.u¦�“"	u	¬
Î
kˆ˜á¸þF´$ÌÉðvQ°EVàžø,µ! 
v«Øþ|¸Ôñ[„ºU	
u„@ö>#ÐGtÒq‰Þ²cœí " áU)Mžƒs”¦U¤mt–‰§íq�¬²Ókš:lÊÍ�Ã  –g`änÃú¶þ¦
ëzÜ9yŒ5>RÔ0�Îa
ÀëÎ‚<, 0 5 O ¯ 3¤\�»•’öcõ•
%©avÎ©¾Äœ Ua†
¨/]§QpG  I!ˆˆU«ç;Ý	Ë	à
ê
:®MXóqÅéŠO=¨[—Ÿa(& Û²Y£¶4»ÀTƒ6	
A
\(TÈGRù|�u×9šè2�Ûô)2–(  % §1>¸¹†“¨¾øÇô‘óÞ
~iIô<ˆ]mwcë¼è‡T0ëÁ 2óÙ	¤`uŠ_¬Þ»ÆÏ�NÄàg?£íB÷) ¡¡©à£«2U`O¢Ý¤	k	ƒ	/
:
„
ˆ
ð
.Î’›ÞjÛ=çE1|nÖ#* 8L‹¯Ò©ªÚ
Éëv	h	‘	¨	Ö	÷	’
 
7€‘<AQdo‚Û½–¾’ôâê™   T ‡ã�E
q4ô_~˜ËÔSh&£°ê~©Ä  × ™Ø²‘Bc[ÈåCpð£˜7¢ß  ŸEûÕõÂ»íÖ&ô€Ê D¾l�
 •½øLÄà z¯ÄÙá iƒÉY¥Úç ÎŽ
¢xµsaz•®§ª½ZµùÐe·½íAÒ�— x ™6¿Â	Fîe€´øˆåé]M�èÀ[¼Âý¸ˆ XÃŠÌç [Ø6ƒüj€E¹ä  Ð g¼¦m	u)—Z“¯ï � cc»É*

­è½×1ÍW«s{’k‡ÆW�„{ „ÇX
Ù
-§	iâOµ÷…{	 €Mêßï§�)D ¿ æ 6ƒY	R
Ñq
74×Á(³6?Ÿ*NÃhcŒóØC t©ü¶3Û-
‚f�s‚‰š v Î ä 4ú&ž -Mãln4vÀ­ù =  Z	(<V¸%àO.3ûx^gû" j Æ YÛ3NWe´šÇ	#Ñ-8Š’š¦«n¹Ïü.[P­Ë…ú+ P\j’ïõ¼Û	üBJluì Vbkw�Œº¤À/? 8B~ £ÍýPâ`•M¯, Ëè÷*WyD"”>	þ	BMtÚ=‰¬ÏÛ#+Xºóh%BÍñý"Š›®tW¶& Ü +ÏÛ$”ß±Ö,Ò#	 	<
z
­
Ï
\‰™ß'­Ð�ëw·ÑozØù¹( ( J Ñ!Bu­Axˆ3UÌ€§ØŽ	+	m	v	J
Š
÷
hÀ¹{?þ±4F¯%P
) bƒ/>v?P|lâüŽß*?Øÿ Gµý'20àTÊRž¡lWáìðŸ"-@" � ’ Ùé£w„”jxÆ»	
¶³Â‘…$HÑÔHwr3hŠ³hî& | ÏâØ`y…F	–	ÿ v‰Ã0“é1ù$8AlÓdDHßÒQ_iì -   w•¬ÿ}¹òŒ\æIâ	¦÷?‘¢-u×;·ä�¡ Š `Õï0>]LV	®	±	Þ	

s
I:AJŠ‚ái~`¬d"+ ¦ &bÂž¾*NŸ QŒòDgßîG	é	4
¸
�¥°î6‘>—QpŠî‚­Ô¿É;Ä ? &;Šâ4þ¨f
N°Ò³äóGp*´‘Ð ì n£°úíX 1q…	{•\n…ÉJXZl›mÎ¯ÿ* ÖGVz¢Ð!†„¤tS	
†
ž
§Vª Wéò:fu”Ýâ"¨5Š3r_l¥!x@Ë0 —C°×
ìøoÝTí�C‹ÁÉƒ~ BÄìîðJ¦@Kˆ6?ÕÝßéb²ý " ÊFh¥[aÊbo·§
ò
T178=:S1žÏ˜¥ó% «Ì¿‘åÓûÿ1

ü{¸zÑ�MìNÏ=- S4O{ìû�Ô¼d¬[šö
%
n
æ
&w´â4ƒL¡¸bÓò;¨7š§R¨XH( 6 l WéÅ–“¿íd¯¢
VªÝbÏðŠ–Å�ç<œìV W©0yq%, ]¥ýJ]Ü÷€a
–
&2‚%.`pë9 ª±Û*q:®‡¸¿KÀÝ<^7Rü, 1 P W ° È ÅHNÇ8�ãA€x“	"
ô
-+4¿˜ðP„­Ä{†U3W¨ºË]´' ù <§V	Ì	á
;NôêFî\˜œõï> 8N	ù	¯C‹[pšæ   õ["jôeqÊèÞ©
õrÆFPwÊu}SÉ>©�oQb) ‡ :Jð‰‰ž¬<BK	›	ª	v
ë
Y\†°5ÀÝÎêð �q" Z — Ì=‘Ü c³«À5UŒ	:Ê)
g!}¶~ôH	¢vØ:*‘ ³ @,KS‹Ì<œ¯7	c	µ	
ý
}Ñc�@ 3õ( ž5ÝR¤"Ä„B
À
Ç
8>SYf{›°UáóÉœ:åþ”›öM¾39›% Ë 'Z·,M¼Á´Ë‚
î
SñÌ]b;ES¦¸úŽ”í#é˜äÜ*— �¹~æj»J/ó+d˜¤­³‡- & •fæ?ãmùƒ¹rŒ’t	“¥ê?õ=xFìpÓ/œÍÑp	ˆ¯¿UÍbÉì�Â. $ 4 02Ú±º3‡”¿÷~õSbòôÊ	@
”
Ý
ß
9LÄè‰'½Ã›`–Œ»81�ê•,  S ¨ò1©¡È	g	j	Ø	‘
p�3P—Ó_t‰ ^n�%ÝM¯½é0}Õ¢áì w`­Ãßb¼ÿ´ÇÏìÕh‚@Ñó6¤–  œ ˜Â¥l³Ö‡5V‚(r†ÅVüî‡ Ð�¦áŽ(M�C* < 3O[iôÚ	Ú2MUajv€‹¹d£™Æ"Ÿ¢Ð7‘3OÎáZO¿¬ùfø6 I Û  ¬VÚax“Õ+=Ñ!O{l	Ÿ	;
I
y
‰
sûÞ>Î×zÏ1Aß>S!š®×ëï$O?! _”è¢Îávƒ“×E	­	Ý	á		
þÂ/Óv�kh2}:«g!( %m‰¢a¯ùÁ3 PWý£Þ„	3
…
�
z�ÿèMe„�“Èo‰Fo¤ kÈ?# ÉªE¤¾¯Aaë¥0
~
Ö
ñ
JS06÷nÐœ Üè—¤LÈ±/ V RMŒÓè«ÛâìZw®’	m
¡
å
,1�_%ÿïÚæpƒÃz…¾JV§¿ÊÜx  ô9ó�©	ø	BEEvZoí
åîP% +Q;ªLÃÊb	‹	´	�
Æ
ü
7ð=Raeš |:D¥äìb"“õãš å°2	i	s	É	×	“
8o’}åº¼ÂÜ•—²ë  NhÏÙL€TiÂUà'6…LU�€•, $^lˆÈ®øDu‚Ùw ž	
H
œ
Õ
ry5öÁÍÖdyƒ�Çn€ÿ­ÇªÇ   U óäç­È	0$þD`™îDYnåU¦±Éë(  fgñò­÷¬
F
G
õÀÌÕXmŽRST¤¥IJK¬ÅÆ  0B  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                     ,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      	                                                                               	                                                 
                                                                                                                                (          	                                  	          	                              #                                        
                                                                       	                  )                        	   	                                              	      	                                       *         +         &         +   “   l      (         "      o                                                                                                                                                                ,                                                                                                                                                                                                                                                                                      	                             	                 
                                              (    	            	    	          #              
                         	      )        	 	                	  	             *   +   &   + “ l  (   "  o   ~
  t  ž  Ú  „ˆ  ‰Ú  �¼1Ôl“oìÝ$å“ª ¬ø	þD‹¦Æßh(Îå{bò
fxÞ&J WÖ”¡Vn2–¡ÓQç„£
X£
MÇ½IòâµX¤
.¤
.xsè0¾ MÇçkƒ½‡ÉIR$*-3³Ë
4Omè0c²¸°¦¬!Et ,€Ã5nò¬}s$´¼
üš8
w‹k{ÅššÔˆdk‰{šk{8
kškbbì1Dé	ò
�px~ŒÓsÎ!¶sÄ1

®1
×­		
}Ós¢Ós S8
¢!
  
9„Ò}S<åè² ‹îÂuË¶âž©í�¹æ'wÒªÆÒªu›]êr§ú´1+
:é
‰�#\á+Â„<W”^Ê”�,¶¾áLM"ÐXÁÇW	P
aÖÎa–±e~ ·–9–V<ì',*×
r§ú´1+
¾|Ë˜‹<ã ø ¦ -šþÐÚ
,ê@Æ Ð@~Ìÿ \£ [+íÊh~ ÐÌ…â@ ¬7
-šÌÁå”(ì�³¾¡µ�¯í5PÚñ�×Ë£
Þ ‚H
y­j<ô
 ðÎq@H¾ˆú Ê” �¬ÖÓ¡€	7
�
OvÌ,•¡¶Ñ¾á$KLªÓ¦ôûdòj	ÝÕv¹Fpˆìï¶qsÃK×
ÝíaÁwx¯Þ Z3
r$Í�³íbo¦WÞÔg£å¡¶lvþ³ÎÐLÓßÚg	‘
�aÖ$
³á·6ÈÇa¯Wï„aÁÞ3
�oÍ  -šþÐÚ
ÌÁå”…â,ê(@Æ)¤ÓÃ‰aÁÞ3
�ío¿Œ•pÉîw Mz~ÆÊö�<zEú«¯=KvÚí"5Sè*0LPy}³Î5R¿:gîaÁ¯Þ3
�o�½íF	¯í5PK  ¬×7
j`è„�åññÏ ftVWéÝ5ö
¿	Fò
S1%…Óø¿ÓÀóÙ	`uŠNà-šûd–V<ìò',j	ÝÕ*Ø žl"
+·Ÿï7âf
ç �Ž™ ç ÀÐ:.
é
Ú"‰�@%  Í ¸)4UëTõ	:
 
ë¤Î#Ðh Ì&GŒBïu×9‰ÓÖÃ  ã Ä|a v³Î>Úß'TZOù²†û~ô
ð>ß'T�‹<¹~Fpvˆì¢š Ôp…K®æ¯i¹I) Ò"Cv^5| {ÚU	  ¬7
3j`è„åñ ¡­Ø�	8
¹Ù=�òÂRVŒÓx«!Zm
å
s%ÎA!š§¦·’ó�ÀqsÔ	'ÃÇ 7@*3)—ü&O¬/V§¹\� k³!Ø LÖÔ�	PvÌÍåÃªù
èÂbÇ�6•e÷¶â–ÓZKäúþzyëÎ<ÖÔ�	vÃ
è)ü&/� k!Ç 7@*3—O¬V§¹\³ £…
�
ÿèe“‰¤ ?áæú%\
ÖK÷´Yì¥; Ç 7@*3)¸c—¢ü&O¦©¬˜ø!/¡V§¹¼2Í\� k³!€eRVŒÓx«!Zm
å
s%ÎÂbAÇ!š§�6•¡…Vñ9á!42^w/8 h¹ŸžvINc3‚K™¦WI  ¬l	I
‰
z>®$OåF$µ
[
¶¸-öÕÐt†
ž
fl!@& æ?Œ’t	¯Ul éídbÏÅVqš1ÙÓH\ÉâÊRC½\wü2Ë×Ÿ	*	go”ê8÷9­�à'ý36& l ³ æ?é¯ídŒ’t	
bÏÅV¯Uq­x3	+	m	v	J
÷
À±F¯
F[bò
T7:S1ž˜¥%þ|Ël«™NhÙLTi6AZäo¬ “dà&kõûÓ	ô	>
Ž%¤*^˜½a¢íy{3*
1Wf{�k‚‰5 ž#Þ•’c"	¬
Î
ˆ˜©aÎ¤ÄœôUºvÄ%¨/íøpLÊ�
ða:D¥ì"ã–#'³»
)EöZ7Žë#_i|Þý˜
(".8j kª6�»T© pÍÉ¡îø�Y¶»À\Rù�èÛ)–à&ûô	y“dkõ>
Ž%^¢{#_iÞý˜
(.8j�T¬ Ó	¤*˜½aí; ¸c¢¦©˜ø!¡¼2Í€eF­[x3b	+	m	v	J
ò
÷
TÀ7:S1ž˜¥±F¯
%§ i+!hà¹
ë«_�T¦j™ DúBv Î ä 4ú&ž -Mãln4vÀ­ù< 3O[iôÚ	Ú2MUajv€‹¹d£™Æ"Ÿ¢Ð7‘3OÎáZO¿¬ùføkŒ	¼ÔA¦©ÁøZäoy¼ÃØÈXÙ€É* Ô Óì#Dw•ÿ_�Å	bð_… .y�›áHcšÈ ?²½@Q™	
#à‡ˆÈþ(òš ¶UË­56< ßu Å û'AI·¿ÿ$.LN2â,m‰ª¸û_w ]®úù <§V	Ì	á
;NôêFî\˜œõï>   ¡­¹ØSå�	8
¤
¬¢ß!4k¹
aÙé=…�˜æò[°Âðò'Ù LÏq	QÍæt±·ëb—²f1ãªúw`­Ãßb¼ÿ´ÇÏìÕh‚@Ñó6¤–¦ &bÂž¾*NŸ QŒòDgßîG	é	4
¸
�¥°î6‘>—QpŠî‚­Ô¿É;ÄG … • Ù "LU.6Qy}�›ØêùáîHc}¾Ã*0šÈ ;?²½Ï@Q}Š˜`	q	™	
_
�
¾
Ó
ã
HQm£è#)2QÍãýÂÊàæy‡•ætˆÑ”±·Èßëñþbs{–¯(Nš«¾ý)3D—²¶Ûò¶Ñš ¶êÿUf¸Ë1K­5:S¢ãî6žªÓíñú<– ß ? ¦ à &(*;‚Šâä&.b#%kÂ4ž¾õ*NfŸ QrŒ¤òþDgß	-¨Äßî9	G	·	é	4
f
h
¸
ö�œ¥°Ç^åî-6N‘©>~—°QpŠÒªî‚Š­³äóG�ÁÔ p“¿É*;}´‘ÄÐs¨ûLµ2X	,
Q
Ø
pÞ	3îÂb×  ¤ Éõ ÈhÿvÑäBo”	d
õ
;Uçð/8«÷Rñ ®VXAfµÐ( ¡ [¸Ol�¥	ã	R—¢¦ø@œ:ÇØ#ü.-å°2	i	s	É	×	“
8o’}åº¼ÂÜ•—²ëe ÓÖëñ7fˆ¯
›ßâï�ÊM˜Ñ¯µÚÝé1qù^vy½J›D ‚  ]†Œ=þ
Ô~�š¤!\ÅùþA,SÀf … s¨û*Lµ.y�›áòHcòKzšµÈá ?²½Â28@QYX	Š	™	³	
,
Q
l
€
°
Ø
+œãð#>^|+hàp‡¹Þ	ˆÈþYÙ(3{Âîò„°”š ¶IUËz­Û&5¾!6ÂíO<b ß×Wº5Ë	¬ç¼0Ìäªi–‘j  %e      p  v         v¿þ`�îÒu¸îód¥=&ã¿ŽˆŠ,á$ŒÄÕjS�uC¡ñÖ�…ã¤
C*Œã¬Æ'Ñ™Ì¡Úhy)¥’[Zpi+dý™�+Ì§eéÂVÏƒ‡Ï×üý¡ËYaÉŠý’\õ�¯hrÖšœ%xýè4�µ"m˜õ'?ù¡ËXp•ƒóàÚcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'.fSDîàåäEýã§ƒ¦ÅigÞdSƒ“*W¥:	ñ;÷’ôˆ ZãFoMÒ<ìAçT}‡i•aÛuaÔ’?*Wó†Óìx�®J==¸¢£þÿÈúúàP�{÷‹êùeXAZ6Í¢á$"Úæ¸  AÓP€QÖMŽ cæ¸CEôàä ›ýÌþ$Ã6”Ì0")ÌÓ!ó�èôÏäÏÎú³«¯ëêì÷+<:¿ËS¹[ ;ú�+Æ¤Ž§ûõUèi+rHlþ*¬þ¡Ê½ÊêY {¢½^×{_æì.kª™@j�°ù ¥U„á©uV¥ÌZZâˆ‹J@ˆ/ô;ý44RcTØÛµ¤´×Ðˆ/ô;ý44RcTØÛµ¤´×Ù/Ïù{ÏÛóþ^óô¯?k¼ÿ`áåªªjcD<CÏ¸û„æ½’Cª Cä:£UNüè™½ªÁ¸mDtA²¬Øh]F�Í
ï:CšÃ˜x×G[;†<ò+Ã‹LÐü+ª‹Qñø¼#øX^4CLÃ› à÷¯£4â;¢ÞÀP9 1Hðï‹nß£¾<EI½¶Ö0Ã�œèo~?k}LWlÛr{<.‹A†àqDÛ@;3ÓÅâ³ÐíC3cñÃnË!ýƒøèñfØ UƒÎ«�­±â Áó›AÙ2ƒŸÈfŽNƒX:û#©Âló¿Í3lúæÏ®‡ºá0à
Åañõ1Ï×ãÛq±¯|óë˜T(°[*¼<8o½3 nØàJë?×¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸™òÇîNDè2[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘EÒj	¸Îã…=)úÁU‚Nèo]_|à“
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  á<?xml version="1.0"?><Features recycledIDs="16" nextValidID="17"><Feature recentID="15" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3364-3380" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="863-881" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3433-3454" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3388-3394" color="#ffffff" type="standard"/><Segment range="3395-3412" color="#ffffff" type="standard"/><Segment name="-35" range="3413-3418" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="1056" consecutiveTranslationNumbering="1" maxRunOn="1059" maxFusedRunOn="1059" detectionMode="exactProteinMatch"><Segment range="991-1056" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="10" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5359-5463" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3170-3291" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1986-2121" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1094-1318" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1806-2135" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1364-1792" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="2" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3742-4327" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="1" name="Neo" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2202-2996" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5289" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4498-5289" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5290-5358" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ?<Notes>
<UUID>4ff05e09-b66c-469c-8065-75f8cff75ce8</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.5</Created>
<LastModified UTC="6:38:25">2023.8.16</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Ôý7zXZ  æÖ´F !   t/å£à‘] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÉ;_xœº_/Mrûík�ÞtlYÜá®cú«Ud*2åC	)*uÕy®a÷0%8 ÖV!íœú´mþGì	ïhÒµzÝÿÈ»]Ýk;éÔõc\±Ò•©å?uó¾bÅ'}¬ÊÇ8t&§³9*VfP¶SlébN5mßŸ¹
àÉ¯ÖÀ—¾¬Í7>ËNôcô!Pÿ]æŒ!KòB
Eð¹\@÷õûÚrÞ|õÒÅ}d8›r½™Þ%ôµÞ@,&öSTÃž}Un.½¸—Ñ_ÙÎR:1±ã´f1åòˆF*Ó'Íö!ýˆ«cZPW™·JiÃaüè�$÷°îG0`À±¤n¬+ ûó¨�_¨pwö�.PÝð!€}ŠY_80‚oÙìRÍZ|@< ¸g'Dè_î¢ç“ kB|zt:`|0G??xxh` h£t•?îñ&u8a�¾ÆÓE‘¡#eé…—Í~ÝŽâ¡0õŽHgt_G(¹4o~{?üÍ„5&õªM_°Då�Sd‰ÛõÀ(Rã²¿¯�&œ®"IððVDÒUóƒX+Óõ¢FÄâMì}úøæ=—�.Ûü@”Ê‚éÆWº™Š®îjêøÒÉw_G0ïTáñ™]üÚ¾2G9"7hJÛ*ÞËÂ·	DÒÏSi=òÀ¦3ÆŠEÚE–;*2Œ‘ëÐš({ýy$ 7R�,³J`bÌ§Ã 	1»![ Rù¬OEµŒ?ùüâ¤› ¾ê2Ð‰táÃ8¬Âlé[n[2��è60Ê+ö¿gáÄ�‘(¥è';Qµ„Yøû¥0&@�[«—* xì¯F0¢hÛqHt²¿42´±‰!ÿÂf‘M­%ùKå‘õ;G$%ý°Q.Ó&a”$?ã¿Œü>æã©"øûä¡p¬3�òB¬ž[ÍêŠ< îöžLÞ‘ª('š¶i‰ÈÄÀsB"ÕŽ%ïD—¯Ðs‚«éCk9w„íí±@l¡Ù++®uìi/±5lÚóVü‘ajê˜¼’D<™üƒÖ”kû>uéßÅ•>ÊÂ¬}©›˜ÉoSÒ[ÀõxžQ(Acn–”áa‚ŸN$û‰ãÌ¥cV�©>ÇqQÊC|SXq§—zŠþ²i˜hYnŸïáörløäH�Aé\RC­$m6­Ô.�¨BØôÿ�nIízâ’…p8®v„êB©�ÿ†î_wy	a€°×?¥Ý!T?µU¼�„°æ[¦v¦Ï|	9‚¬ž�V�Ý'†KÊzR&V\è>×~[·ÛøNÒ¶ 	ñ?òŸcx¤ŠÃòl’•Ùj†ºu�#•´ÎÞKÔƒˆ&P–”YÇfñExÓ¿aÛíL%îýGœµ¸jÓü"0kF´QC”‘¨E8¤ý‰U;¡–îQ„–7|–»í01'>' Qßæëq�[s~õ]ƒ]61Ü*9öT{	f
ØÆ°·~–/Þ£P‡™ï'ÆNLYMË¯ñÔaœÄÂè>hI&D%hð®'H¼g�”JgÒ©k×gÆôÐR·w¦/ýF¼°ÆUHËñ¶�9ÈYj» ˜äŒb†Ü»èðF÷³a9¬Ä@gñ¨u�çBé‹ÑˆR¹ZÓ$Ù¯ôñöjÎ#VähÿCzòE9v’	˜™äég~`/:£–c‚Í@�è{�„Ä¬ÞEÒ†=¼L‰ÚÅ·V³.­Ê™¯�8�»0°(¼J8f2g”}OÏpÄkÒGŽšV¯]ñ—ß¯¡BKYâÒköM<Og+nßÊŒ‡i]V'z¹Êè,Z[š)�”˜cµB)M/Cïëás„�gM—ÜyvâRÛ?ÜîPÀP¢ÎÅc•ÛÛ¨õù)jcjPhÀ	kYlOí?\ónRxí+DˆFóÂÊ¹W¯ŸÀc”1|E;·.È›ƒ
’SÉ_¤à~Bƒóü =–Û{ëþ½ýÿçCfDï<¥²B-ät‚Ú}Ò
„„|òØüPÍÎLöÃ§þX¾Ä¢ÈÑ:Ýæá°–U�\3Ô¥n�†«d!§‡–P-z¢Þvƒ11âÆ|&æ�]9¡=ý‡‰5 ×Lµß°EîRªÐ%ÑEà®84by�·ù0ÿ‡�Ë€°}(Ùòh€     ŸÙƒü”8Š¾ ­†0  +r±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  &'<?xml version="1.0"?><Features nextValidID="18"><Feature recentID="0" name="ZP2" directionality="1" translationMW="82358.94" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3273" maxFusedRunOn="3273"><Segment range="964-3198" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MACRQRGGSWSPSGWFNAGWSTYRSISLFFALVTSGNSIDVSQLVNPAFPGTVTCDEREITVEFPSSPGTKKWHASVVDPLGLDMPNCTYILDPEKLTLRATYDNCTRRVHGGHQMTIRVMNNSAALRHGAVMYQFFCPAMQVEETQGLSASTICQKDFMSFSLPRVFSGLADDSKGTKVQMGWSIEVGDGARAKTLTLPEAMKEGFSLLIDNHRMTFHVPFNATGVTHYVQGNSHLYMVSLKLTFISPGQKVIFSSQAICAPDPVTCNATHMTLTIPEFPGKLKSVSFENQNIDVSQLHDNGIDLEATNGMKLHFSKTLLKTKLSEKCLLHQFYLASLKLTFLLRPETVSMVIYPECLCESPVSIVTGELCTQDGFMDVEVYSYQTQPALDLGTLRVGNSSCQPVFEAQSQGLVRFHIPLNGCGTRYKFEDDKVVYENEIHALWTDFPPSKISRDSEFRMTVKCSYSRNDMLLNINVESLTPPVASVKLGPFTLILQSYPDNSYQQPYGENEYPLVRFLRQPIYMEVRVLNRDDPNIKLVLDDCWATSTMDPDSFPQWNVVVDGCAYDLDNYQTTFHPVGSSVTHPDHYQRFDMKAFAFVSEAHVLSSLVYFHCSALICNRLSPDSPLCSVTCPVSSRHRRATGATEAEKMTVSLPGPILLLSDDSSFRGVGSSDLKASGSSGEKSRSETGEEVGSRGAMDTKGHKTAGDVGSKAVAAVAAFAGVVATLGFIYYLYEKRTVSNH"/></Q></Feature><Feature recentID="1" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="958-967" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5578-5594" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="863-881" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5647-5668" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="5602-5608" color="#ffffff" type="standard"/><Segment range="5609-5626" color="#ffffff" type="standard"/><Segment name="-35" range="5627-5632" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3270" consecutiveTranslationNumbering="1" maxRunOn="3273" maxFusedRunOn="3273" detectionMode="exactProteinMatch"><Segment range="3205-3270" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="DYKDHDGDYKDHDIDYKDDDDK"/></Q></Feature><Feature recentID="7" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7573-7677" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5384-5505" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4200-4335" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3308-3532" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4020-4349" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3578-4006" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5956-6541" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="Neo" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4416-5210" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="17" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7503" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6712-7503" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7504-7572" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¥<Notes>
<UUID>b9d97e3f-29b9-4157-932a-8929815a640d</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-ZP2(human)-3Ã—FLAG-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="16:0:0">2017.6.5</Created>
<LastModified UTC="7:27:19">2025.9.21</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d               E              ÿÿÿÿYô? P                                                                                                                                                             o<StrandColors><TopStrand><ColorRange range="959..972" colors="green"/><ColorRange range="1069..1069" colors="magenta"/><ColorRange range="1481..1481" colors="magenta"/></TopStrand><BottomStrand><ColorRange range="959..972" colors="green"/><ColorRange range="1069..1069" colors="magenta"/><ColorRange range="1481..1481" colors="magenta"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
